United field an unchanged line-up from the 1-1 draw against Wolves. Aaron Wan-Bissaka appears against his former club for the first time.
Scott McTominay makes his 50th appearance in all competitions for the Reds.
Anthony Martial leads the line once again, and will be aiming to continue his fantastic start to the season.
Manchester United XI: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Pogba, McTominay, James, Lingard, Rashford, Martial
Subs: Mata, A Pereira, Young, Romero, Greenwood, Matic, Tuanzebe.
Crystal Palace XI: Guaita, Kelly, Ward, Cahill, Van Aanholt, Milivojevic, Kouyate, Schlupp, McArthur, Zaha, Jordan Ayew
Subs: Dann, Meyer, Townsend, Hennessey, Benteke, Wickham, McCarthy