Ole Gunnar Solskjaer has made three changes to the team by recalling Nemanja Matic, Paul Pogba and Diogo Dalot, in the places of Eric Bailly, Scott McTominay and Andreas Pereira.
Mason Greenwood is also on the bench, fresh from making his first-team debut during Wednesday night’s epic Champions League win over Paris Saint-Germain.
Arsenal XI: Leno; Sokratis, Koscielny, Monreal; Kolasinac, Xhaka, Ramsey, Maitland-Niles; Ozil; Lacazette, Aubameyang
Subs: P. Čech, Mustafi, D.Suárez, M.Elneny, A. Iwobi, M. Guendouzi, Nketiah
Manchester United XI: De Gea; Young, Shaw, Lindelof, Smalling; Pogba, Matic, Fred, Dalot; Rashford, Lukaku.
Subs: Sergio Romero, M. Rojo, A.Martial, A.Pereira, Bailly, S. McTominay, M. Greenwood